2 T-helper 1 cell differentiation Apoptosis 12.5 negative regulation of
LPS-mediated signaling pathway Adipocytokine signaling pathway 12.3 negative regulation of smooth muscle cell migration Prostate cancer 11.4 regulation of MAP kinase activity chemotaxis Toll-like receptor signaling pathway 11.1 protein amino acid dephosphorylation T cell receptor signaling pathway 10.5 neutrophil activation B cell receptor signaling pathway 9.9 entrainment of circadian clock 6 Phosphatidylinositol signaling system 32.2 anti-apoptosis click here No significant GO Epithelial cell signaling in Helicobacter pylori infection 15.5 regulation of retroviral genome Small cell lung cancer 14.2 replication Pathways in cancer 12.4 T-helper 1 cell differentiation Apoptosis 11.6 neutrophil activation Adipocytokine signaling pathway 10.1 negative regulation of I-kappaB Toll-like receptor signaling pathway 8.9 kinase/NF-kB cascade MAPK signaling pathway 8.7 induction of positive chemotaxis Bladder cancer 8.5 myeloid dendritic cell differentiation B cell receptor signaling pathway 8.3 12 selleck Leukocyte transendothelial migration 309.7 cell cycle arrest response to unfolded protein Cell adhesion molecules (CAMs)
75.4 amino acid transport S-adenosylmethionine biosynthetic process DNA replication 25.0 positive regulation of transcription Cell cycle 20.0 response to stress Pathways in cancer 19.4 regulation of MAP kinase activity Dichloromethane dehalogenase p53 signaling pathway 17.0 Antigen processing and presentation https://www.selleckchem.com/products/ew-7197.html 15.7 MAPK signaling pathway 13.2 Small cell lung cancer 12.2 Circadian rhythm 11.9 24 Leukocyte transendothelial migration 80.3 keratinocyte differentiation cholesterol biosynthetic process Cell cycle 24.4 amino acid transport response to unfolded protein p53 signaling pathway 20.9 keratinization isoprenoid biosynthetic process Circadian rhythm 18.6 angiogenesis creatine biosynthetic process DNA replication 18.0 apoptosis response to oxidative stress Adherens junction 16.1 response to stress Pathways in cancer 14.9 cell cycle arrest Nucleotide excision repair 14.3 pyrimidine nucleotide
metabolic Ubiquitin mediated proteolysis 14.2 process Phosphatidylinositol signaling system 13.7 induction of positive chemotaxis Significantly impacted KEGG cellular pathways and enriched Gene Ontology terms (biological processes only) (p < 0.05) at different time points following co-culture of H. pylori and AGS cells. Top 10 pathways/ontologies included where number exceeds 10. IF = impact factor Because GO analysis simply associates differentially expressed genes with the ontologies, there is no attempt at ranking the true biological significance of individual genes or ontologies. Therefore, we included only genes with a log2FC > 1.5 in the GO analysis, excluding lesser significantly expressed genes that were likely to result in erroneous GO ranking.