3 mL, P < .001) and greater loss of systolic wave height in the distal
aorta (30% +/- 16% vs 22% +/- 12%, P < E7080 molecular weight .01) compared with that of subjects with a Romanesque arch. Pulse wave velocity was also increased with a Gothic arch (5.6 +/- 1.1 vs 4.1 +/- 1 m/s, P < .0001), as well as left ventricular mass index (85 +/- 15 vs 77 +/- 20 g/m(2)). Patients with a Romanesque arch had increased aortic stiffness compared with that of control subjects (stiffness beta-index, 3.9 +/- 0.9 vs 2.9 +/- 1; P = .03).
Conclusions: Angulated Gothic aortic arch is associated with increased systolic wave reflection, as well as increased central aortic stiffness and left ventricular mass index. These findings explain (at least in part) the association between this pattern of arch geometry and late hypertension at rest and on exercise in subjects after coarctation repair.”
“Destructive effect of superoxide anions O-2(-) derived from KO2 or xanthine-xanthine oxidase system on dinitrosyl-iron complexes bound with bovine
albumin or methemoglobin (DNIC-BSA or DNIC-MetHb) was demonstrated. The sensitivity this website of DNIC-BSA synthesized by the addition of DNIC with cysteine, thiosulfate or phosphate (DNIC-BSA-1, DNIC-BSA-2 or DNIC-BSA-3, respectively) to destructive action of O-2(-.) decreased in row: DNIC-BSA-1 > DNIC-BSA-3 > DNIC-BSA-2. The estimated rate constant for the reaction between O-2(-.) and DNIC-BSA-3 was equal to similar to 10(7) M-1 s(-1). However, hydrogen peroxide and tert-butyl hydrogenperoxide (t-BOOH) did not induce any noticeable degradation of DNIC-BSA-3 even when used at concentrations exceeding by one order of magnitude those of the CDK inhibitor complex. As to their action on DNIC-MetHb both hydrogen peroxide and t-BOOH-induced rapid degradation of the complex. Both agents could induce the process due to the effect of alkylperoxyl or protein-derived free radicals formed at the
interaction of the agents with ferri-heme groups of MetHb. Peroxynitrite (ONOO-) could also initiate protein-bound DNIC degradation more efficiently in the reaction with DNIC-BSA-3. Higher resistance of DNIC-MetHb to peroxynitrite was most probably due to the protective action of heme groups on ONOO-. However, the analysis allows to suggest that the interaction of protein-bound DNICs with O-2(-.) is the only factor responsible for the degradation of the complexes in cells and tissues. (c) 2007 Elsevier Inc. All rights reserved.”
“Objective: The purposes of this study were to evaluate the histologic characteristics of the aortic wall and the risk factors related to histopathology and aortic dilatation in patients undergoing intracardiac repair of tetralogy of Fallot.
Methods: Operatively excised full-thickness aortic wall tissue from 98 consecutive patients undergoing intracardiac repair of tetralogy of Fallot aged 6 months to 47 years (mean 104.5 +/- 102.8 months; median 72 months) were studied by light microscopy.