Existing epidemiologic studies indicate that the use of Bosutinib Src Swedish snus��a smokeless tobacco product low in TSNA��even though associated with an increased risk of pancreatic cancer when compared with never-users of any tobacco is not related to lung cancer and that the risk of oral cancer, if it exists, is very limited (Greer, 2011; Luo et al., 2007). Because of their potential for reducing exposure to TSNA and other carcinogens that are present in cigarette smoke, the use of low-TSNA smokeless products is seen by some as a potential harm-reduction strategy (Bates et al., 2003; Levy et al., 2004). Another critical chemical in smokeless tobacco is nicotine, the main known addictive constituent.
Both total nicotine and unprotonated nicotine content��the biologically available form of nicotine that depends on the pH of the product��are critical in consumers�� acceptance of a smokeless tobacco product and potential addiction to it (Fant, Henningfield, Nelson, & Pickworth, 1999; Henningfield, Fant, & Tomar, 1997). Initial analyses revealed that single pouches of Marlboro Snus, Camel Snus, and similar products contain relatively low levels of TSNA and nicotine as compared with conventional moist snuff, implying lower carcinogenic and addictive potential (Stepanov, Jensen, Hatsukami, & Hecht, 2008). However, information on chemical composition of these products is limited, and the extent of variability of TSNA and nicotine in a particular product because of manufacturing methods, the way the product is stored, or because of the intent of the manufacturer is unknown.
This information is essential in view of continuous modifications that this new category of products undergoes as it is being test marketed. Moreover, the potentially important role of TSNA and nicotine levels in labeling and marketing regulations, as well as in the establishment of standards for tobacco products as a part of Food and Drug Administration (FDA) regulation, makes the ongoing evaluation of these toxicants particularly important. The New Product Watch is a web-based national monitoring network made up mainly of state tobacco program staff and their community partners. It provides tools for monitors to periodically report local observations of new oral tobacco products being sold locally. Results are posted online for use by members around the country. Drug_discovery Twice a year, monitors collect product samples for analysis of chemical constituents and product packaging (Rogers, Biener, Nyman, & Crow, 2010). We present here the results of TSNA and nicotine analyses of Marlboro Snus, Camel Snus, and Camel Dissolvables that were purchased as part of the first phase of the New Product Watch project.