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“The present study was undertaken to evaluate the effect of glyceryl monostearate (GMS) and stearic acid (SA) on the release profile of gliclazide from the matrix. Matrix tablets for the controlled delivery of gliclazide were prepared by hot melt method using pure and blended

mixture of glyceryl monostearate and stearic acid in different drug to polymer and polymer to polymer ratios. In vitro release characteristics of gliclazide from these hydrophobic matrices were studied over 8 h in phosphate buffer media of pH 7.4. The release kinetics of drug was evaluated for zero order, first order, Higuchi and Peppas kinetic models. It was observed that the Sapanisertib inhibitor release of drug from the matrix selleck compound was greatly retarded by GMS and retarding effect increased with increasing polymer to drug ratios. On the other hand SA appeared to channel the drug from the wax matrix and release was greatly increased with increasing polymer to drug ratios. The kinetic evaluation of release profile indicated that the Higuchi model was the most appropriate model for describing the release profile of gliclazide. The application of Peppas biexponential equation indicated that non-Fickian release was the predominant mechanism of drug release. The FTIR results showed no interaction between the drug and the polymers and DSC results indicated that both the drug and polymers are in amorphous state

and no significant complexes were formed. The results indicated that proper selection of drug to polymer and polymer to polymer ratios were important in order to achieve the desired dissolution profile in these learn more matrix tablets.”
“The deposition of chlorhexidine base on thermosensitive N-isopropylacrylamide polymeric microparticles was assessed in this study using energy dispersive X-ray spectrometry (EDXS) in scanning electron microscopy (SEM) setting. Three different types of polymer were synthesized.

The PN1 was a polymer with terminal anionic groups resulting from potassium persulphate initiator. The PN2 was synthesized with 2,2′-azobis(2-methylpropionamidine)dihydrochloride, what resulted in cationic amidine terminal groups. The PN3 had anionic terminals, however increased hydrophobicity was maintained with N-tert-butylacrylate functional groups. The thermosensitivity of the polymer-chlorhexidine complexes was confirmed by the turbidimetric assay. The deposition patterns, observed in/on the polymers give the assumption to develop the applications of evaluated polymers as factors influencing chlorhexidine release from the topical formulations.”
“This article reports the validation of a spectrophotometric method to estimate coumarins incorporated into nanoemulsions containing Pterocaulon balansae Chodat extract. The quantification was based on the assay of esculin at 327 nm, which presents the same substitution pattern of coumarins isolated from Pterocaulon species. Linear response (R(2) > 0.