Increasing sensitivity will be of benefit in compensating for the relatively low power of current high resolution continuous wave THz radiation techniques, and to fully express the potential of THz spectroscopy as source power increases. Improved sensitivities, and thus scanning speeds, will allow detailed studies of the complex vibration-rotation-tunneling

Citarinostat order dynamics that large molecules show at THz wavelengths, and will be especially important in studying more elusive, transient species such as those present in planetary atmospheres and the interstellar medium. Coupling radiation into the cavity presents unique challenges at THz frequencies, however, meaning that the cavity configurations common in neighboring frequency domains cannot simply be translated. Instead, novel constructions are needed. Here we present a resonator design in which wire-grid polarizers serve as the input and output coupling mirrors. Using this configuration, Q-factors of a few times 10(5) are achieved near 0.3 THz. To aid future investigations, the parameter space that limits the quality of the cavity is explored and paths to improved performance highlighted. Lastly, the performance of polarizer cavity-based Fourier transform (FT)

THz spectrometers is discussed, in particular those design optimizations that should allow for the construction of THz instrumentation this website that rivals and eventually surpasses the sensitivities achieved with modern FT-microwave cavity spectrometers. (C) 2011 American Institute of Physics. [doi:10.1063/1.3560771]“
“Objectives: The aim of this study was to evaluate the effect of the G3057A (rs62589000) LEPR polymorphism on obesity risk

and plasma leptin, insulin, and lipid levels in a sample of the Tunisian population.

Design and methods: Three hundred and ninety-three obese patients and 317 controls participated in this study. The G3057A genotype was determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis.

Results: In the entire study sample, no significant differences in HDAC inhibitor genotype frequencies were observed between obese patients and controls. However, stratified analysis by gender revealed a quantitative increase in the variant allele (33.3% vs. 25.8%; chi(2) = 4.90, p = 0.026) in obese women (but not men) compared to controls. When a dominant model of inheritance was assumed, the GA + AA genotypes were more prevalent in these obese female patients than in controls (58.3% vs. 47.8%; chi(2) = 4.08, p = 0.044). Unconditional logistic regression showed that in women only, obesity risk was significantly higher for homozygotes for the variant allele (OR = 2.73, 95% CI 1.03-7.21) and for carriers of GA + AA genotypes (OR=1.53, 95% CI 1.01-2.31) compared with homozygotes for the normal allele. The association between the G3057A LEPR variant and obesity remained statistically significant even after adjustment for age.