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allergy is one of the important occupational health problems among medical doctors. At present, about 287,000 doctors work in Japan. The number before of doctors per hundred thousand of the population in Japan is ranked low compared to other OECD member countries, and Japanese medical doctors must work excessively long hours. Decline of work efficiency and of QOL caused by work-related allergies is not only a personal problem but can also contribute a substantially to loss of human resources for community health. Allergic diseases have been increasing and are prevalent worldwide especially among children and young adults (Pearce et al. 1993; Ng and Tan 1994; Lundbäck 1998; https://www.selleckchem.com/products/cb-839.html Devereux 2006; Norbäck et al. 2007). On the other hand, the increase has reached a plateau in some developed countries (Ronchetti et al. 2001; Zöllner et al. 2005). However, allergic diseases are common and represent a considerable global health problem at present.