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“Introduction Bone remodeling depends on the balance between bone resorption and bone formation . Postmenopausal osteoporosis reflects an imbalance in bone remodeling in which osteoclastic bone resorption exceeds osteoblastic bone formation . The ovariectomized (OVX) model has been used as an animal model for various clinical syndromes derived from osteoporosis . The serum concentration of C-terminal telopeptides of type I collagen (CTx) and the serum activity of alkaline phosphatase (ALP) are markers of bone resorption and bone formation, respectively . Previous research has shown that CTx and ALP are significantly greater in an OVX group than in a sham-operated group .