22 and 30 Oral biofilm are one of the factors that contribute to caries development. Natural substances that can optimize the biofilm reduction or eradication could act as adjuvant in therapy for patients with high risk to tooth decay. Casbane Diterpene showed, for the first time, antimicrobial effect on planktonic forms and biofilm of oral pathogens. These results are very important, because very few natural products are known to inhibit the growth of oral pathogens, some of which (including Streptococcus) are responsible for dental plaque. 36 So this natural compound can be considered as a promising molecule with potential for treatment against oral Vincristine mouse pathogens responsible for dental plaque.
Additional toxicological studies need to be performed to validate its applicability. The research had a financial support from CAPES, CnPq, FUNCAP and Brazilian foment institutions. There is no interest conflict. The saliva collection had a project approved by the Ethical Committee from Universidade
Estadual Vale do Acaraú-UVA, under the reference number 217-CONEP/CNS/MS. We gratefully acknowledge CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico), CAPES (Coordenação de Aperfeiçoamento de pessoal de Ensino superior) and FUNCAP (Fundação Cearense de Apoio ao Desenvolvimento BGB324 cost Científico e Tecnológico) for their finacial support and Prof. E. R. Silveira (CENAUREMN-UFC) for obtaining the NMR spectra. “
“Dental wear is consequence of a multifactorial process involving three synergistic components: attrition (effect of tooth-to-tooth
contact), abrasion (friction against exogenous material, i.e. food items or tool use) and abfraction (microstructural loss of dentine in stressed areas), and normally is related to age progression. 1 Variations in the morphology and structure of the tooth, biomechanics, animal physiology or behaviour may influence the nature and extent of tooth wear among different species of animals. Factors such as crown morphology, enamel hypoplasia and lower resistance to wear, mastication mechanisms, consistency of diet and parafunctional Thalidomide uses of teeth are all potentially related to tooth wear.2 Tooth wear has been reported for captive or commercially valuable animals,3 and 4 early hominids and other primates5 and 6 and also fossil vertebrates.7 Numerous studies of tooth wear in wild mammals have been published in recent years, relating wear of dental tissues with life history aspects, feeding ecology, reproductive fitness, etc.8, 9, 10 and 11 However, the same is not true for those living in the aquatic environment. Dental wear has been reported in a few species of aquatic mammals, including sea lions, manatees and dolphins. Age progression, feeding strategies, behaviour and tooth mineral content were pointed out as factors influencing dental wear in pinnipeds.