001) with no significant group x time Compound Library cell assay interactions observed among groups in changes in bench press 1RM (KA-L 3.22 ± 1.5, KA-H 3.3 ± 6.8, CrM 4.5 ± 3.7 kg, p = 0.73). There was no significant difference observed in hip sled/leg press 1RM over time (449.5 ± 162, 471.1 ± 167, Inhibitor Library p = 0.33)

or interactions observed among groups in changes in hip sled/leg press 1RM (KA-L 8.7 ± 111, KA-H 68.8 ± 96, CrM −13.3 ± 185 kg, p = 0.33) Table 9 shows results for the anaerobic capacity test while Figure 4 presents changes in total work observed for each group. MK 8931 in vivo Univariate MANOVA analysis revealed that average power (p = 0.005), peak power (p = 0.003), and total work (p = 0.005) increased in all groups over time with no significant group x time

interactions observed among groups. Total work performed on the anaerobic capacity sprint test increased in all groups over time (−69 ± 1,030, 552 ± 1,361 J, p = 0.02) with no significant group x time effects observed among groups (KA-L −278 ± 676, 64 ± 1,216; KA-H 412 ± 1,041, 842 ± 1,369; CrM −301 ± 1,224, 775 ± 1,463 J, p = 0.32). Table 8 One Repetition Maximum Strength Variable N Group Day   p-level       0 28     Upper Body (kg) 12 KA-L 95.3 ± 25.4 98.6 ± 24.7 Group 0.89   11 KA-H 98.4 ± 18.2 101.7 ± 17.3 Time 0.001   12 CrM 99.12 ± 24.0 103.7 ± 26.1 G x T 0.73 Lower Body (kg) 12 KA-L 445.3 ± 182 454.1 ± 155 Group 0.52   12 KA-H 465.4 ± 117 539.0 ± 163 Time 0.35   12 CrM 439.1 ± 189 425.8 ± 175 G x T 0.31 Values are means ± standard deviations. Data were analyzed by MANOVA with repeated measures. Greenhouse-Geisser time and group x time (G x T) interaction p-levels are reported with univariate group p-levels. Figure 3 Changes in bench press 1RM strength from baseline. Table 9 Wingate Anaerobic Sprint Capacity Variable N Group Day   p-level       0 7 28     Mean Power (W) 12 KA-L 658 ± 136 651 ± 134 660 ± 138 Group 0.61   11 KA-H 689 ± 99 703 ± 113 717 ± 114 Time 0.005   12 CrM 660 ± 119 652 ± 108 688 ± 105 G x T 0.21 Peak Power (W) 12 KA-L 1,274 ± 259

1,393 ± 286 1,585 ± 526 Group 0.50   11 KA-H 1,329 ± 285 1,538 ± 389 1,616 ± 378 Time 0.003   12 L-gulonolactone oxidase CrM 1,478 ± 376 1,626 ± 281 1,571 ± 409 G x T 0.48 Total Work (J) 12 KA-L 19,728 ± 4,076 19,450 ± 3,910 19,792 ± 4,153 Group 0.59   11 KA-H 20,681 ± 2,968 21,093 ± 3,387 21,523 ± 3,432 Time 0.005   12 CrM 19,799 ± 3,564 19,497 ± 3,210 20,573 ± 3,128 G x T 0.22 Values are means ± standard deviations. Data were analyzed by MANOVA with repeated measures. Greenhouse-Geisser time and group x time (G x T) interaction p-levels are reported with univariate group p-levels.