The true-positive, false-positive, false-negative and true-negative were found in 83%, 17%, 0% and 100%. Then, JAK inhibitor the sensitivity, specificity and accuracy were 100%, 38% and 84% (Table 7). Lymphoscintigraphy with 99m-Tc-HSA-D might be somewhat different from 99m-Tc-Re in findings depending on the different component from that of 99m-Tc-Re [24]. Dynamic and static lymphoscintigraphy with 99m-Tc-HSA-D were performed in 14 patients with squamous cell carcinoma of the head and neck. We injected 74MBq of 99m-Tc-HSA-D subcutaneously

in both areas behind ears. Dynamic and static lymphoscintigraphy were carried out. The criteria of metastasis were almost the same as those of 99m-Tc-Re. Nine of 14 patients were proved to be metastasis pathologically and they all showed a positive lymphoscintigraphic image (true positive). 5 of 14 patients were proved to be normal pathologically. They all showed a positive lymphoscintigraphic image (false positive). The true-positive and false-positive were found in 64% and 36%. Then, the sensitivity and accuracy were Sorafenib research buy 100% and 64% (Table 8). All patients proved to be metastasis pathologically showed a positive lymphoscintigraphic image (true positive). 4 of 5 patients proved to be normal pathologically showed a positive lymphoscintigraphic image (false positive) and 1 patient revealed a negative image (true negative). The true-positive, false-positive, false-negative

and true-negative were found in 69%, 31%, 0% and 100%. Then, the sensitivity, specificity and accuracy were 100%, 20% and 71% (Table 9). 99m-Tc-Re was composed of uniform particles of a suitable size for the pores. 99m-Tc-Re flew through small lymphatic vessels, then reached lymph nodes. On the other hand, 99m-Tc-HSA-D did not consist of any colloidal particles [10] and [11], therefore the mechanism of uptake of this radioactive agent in lymph nodes was very different from that of 99m-Tc-Re, and because of this Inositol monophosphatase 1 their lymphoscintigraphic patterns were assumed to be different in some degree. The sensitivity, specificity and accuracy of lymphoscintigraphy with 99m-Tc-Re and 99m-Tc-HSA-D were shown in

Table 10. In comparison of 99m-Tc-Re with 99m-Tc-HSA-D, 99m-Tc-Re showed a high accuracy both in the dynamic and static lymphoscintigraphy, and was estimated to be superior to 99m-Tc-HSA-D as an agent for lymphoscintigraphy. This might depended on the component of each agent: 99m-Tc-Re was consisted of colloid and 99m-Tc-HSA-D was dextran. We made re-evaluation of some of our previous reports [3], [4], [5], [6], [7], [8], [9], [10] and [11] on scintigraphy for malignant tumors and lymph node metastasis. There were some clues to find a solution to problems in scintigraphy. The results in this article indicated a possible hint to make a qualitative diagnosis of malignant tumors or to differentiate malignant tumors from inflammatory lesions.