The formulations were evaluated for patch thickness, tensile strength,
moisture content, water absorption capacity and drug content. In vitro drug release and permeation of the patches were determined using a Franz diffusion cell.
Results: the tensile strength of all the formulations was in the range from 6.09 to 9.85 Mpa indicating Ricolinostat that the [patches were strong. Maximum drug release in 8 h for dibutyl phthalate DBP and dibutyl sebacate DBS patches was 38.9 (DB6) and 53.4 % (DS3), respectively, which are significantly (p < 0.01) higher than the lowest values of 17.8 (for DB1) and 35.0 % for (DS5), respectively. Drug release rate was 1.89 and 3.93 mu g/h/cm(2), respectively with DS2 and DB2 showing the highest permeation rate of 5.39 mu g/h/cm(2). Patches containing DBP followed Higuchi release model while patches formulated with DBS followed first order release kinetics.
Conclusion: Ondansetron matrix-type transdermal patches formulated with suitable amounts of chemical enhancers for better patient compliance are feasible.”
“Fusionless growth modulation is an attractive
alternative to conventional treatments of idiopathic scoliosis. To date, fusionless devices achieve unilateral growth modulation by compressing the intervertebral disc. This study explores a device to control spinal alignment and vertebral morphology BMN 673 DNA Damage inhibitor via growth modulation while excluding the disc in a porcine model.
A device that locally encloses the Navitoclax vertebral growth plate exclusive of the disc was introduced anteriorly over T5-T8 in four immature pigs (experimental) while three underwent surgery without instrumentation (sham) and two were selected as controls. Bi-weekly coronal and lateral radiographs were taken over the 12-week follow-up to document vertebral morphology and spinal alignment modifications via an inverse approach (creation
of deformity).
All animals completed the experiment with no postoperative complications. Control and sham groups showed no significant changes in spinal alignment. Experimental group achieved a final coronal Cobb angle of 6.5A degrees A A +/- A 3.5A degrees (constrained to the four instrumented levels) and no alteration to the sagittal profile was observed. Solely the experimental group ended with consistent vertebral wedging of 4.1A degrees A A +/- A 3.6A degrees amounting to a cumulative wedging of up to 25A degrees and a concurring difference in left/right vertebral height of 1.24 +/- A 1.86 mm in the coronal plane.
The proposed intravertebral epiphyseal device, for the early treatment of progressive idiopathic scoliosis, demonstrated its feasibility by manipulating spinal alignment through the realization of local growth modulation exclusive of the intervertebral disc.”
“The improvement of sample-preparation and extraction techniques for determinations of natural bioactive compounds is very important.