The security profile and outcomes could possibly be enhanced more by demonstrably IOX1 chemical structure defining crucial surgical landmarks that may additionally assist tumoral resections in the mesial temporal lobe and selective mesial resections. The authors present their learnings of intraoperative landmarks (cisternal, parenchymal, and vascular) and surgical substeps through an index instance of cortico-amygdalo-hippocampectomy with lessons from 820 resections. The video clip can be obtained here https//stream.cadmore.media/r10.3171/2024.4.FOCVID2428.Selective amygdalohippocampectomy via the pterional transsylvian approach is a feasible option for numerous patients with mediobasal temporal epilepsy. Nevertheless, it may possibly be inadequate for clients as soon as the posterior hippocampal area is included. The paramedian supracerebellar transtentorial approach offers precise anatomical positioning when revealing the entire length of the mediobasal temporal region, including the fusiform gyrus. In addition, this method allows discerning amygdalohippocampectomy without having any neocortical harm. This video clip gift suggestions the successful treatment of a patient with posterior hippocampal sclerosis and mediobasal temporal epilepsy through the paramedian supracerebellar transtentorial approach.Hypothalamic hamartomas (HHs) are harmless masses, frequently associated with drug-refractory epilepsy (DRE). Open surgery in addition to the endoscopic disconnection practices are fraught with a top chance of morbidity and failure prices. The writers being doing robotic-guided radiofrequency (RF) ablation for several types of HH showing with DRE as a typical treatment at their establishment. The writers have actually managed on 25 patients with HH using this method over the last 8 years. This will be a safe, effective, and minimally invasive method. In this video clip article, the writers want to demonstrate their particular technique of RF ablative disconnection under robotic guidance.An accurate concept of the epileptogenic area is critical to your success of epilepsy surgery. When noninvasive presurgical researches are insufficient, stereoelectroencephalography (SEEG) becomes vital. This research illustrates a systematic strategy utilizing predictive protein biomarkers an illustrative instance of centroparietal epilepsy, detailing the stepwise workup, planning, and image-guided robot-assisted frameless stereotactic implantation of intracerebral electrodes. The movie provides insights into technical aspects and a single-center experience. Demonstrating efficacy, protection, and feasibility, SEEG emerges as a valuable procedure for learning drug-resistant focal epilepsy. The video are obtainable right here https//stream.cadmore.media/r10.3171/2024.4.FOCVID2427.Vagus nerve stimulation (VNS) is a neuromodulatory therapy involving chronic intermittent electric stimulation of the remaining vagus neurological, administered through a programmable pulse generator implanted subcutaneously into the upper body. This generator connects to a bipolar lead, with electrodes covered across the vagus neurological when you look at the neck. Mostly used as an adjunct treatment for customers with refractory epilepsy whom cannot undergo or never have benefitted from resective surgery, VNS is generally speaking well tolerated with few severe side-effects. Herein is presented an educational surgical video clip supplying a detailed, step-by-step technical description of VNS implantation. The video can be located right here https//stream.cadmore.media/r10.3171/2024.4.FOCVID244.Epilepsy is a common manifestation of pediatric cavernous malformations. In medically refractory patients, surgery is capable of high seizure freedom prices with reduced morbidity. This video illustrates the employment of a minipterional craniotomy and transsulcal resection of a frontal opercular cavernous malformation in a 13-year-old feminine latent autoimmune diabetes in adults with clinically intractable epilepsy. At 1-year followup, she ended up being assessed as Engel course we with an important enhancement inside her lifestyle. Principles of cavernous malformation resection to treat epilepsy are also evaluated. The video clip are obtainable here https//stream.cadmore.media/r10.3171/2024.4.FOCVID2441.Surgical management of drug-resistant epilepsy (DRE) in customers with multiple periventricular nodular heterotopias (PVNHs) is challenging. Determining the positioning of seizure beginning within these complex epileptic companies is hard, and open resection carries dangers of injury to surrounding useful white matter tracts such optic radiations (ORs). The writers show tractography-assisted laser ablation of just one nodule in someone with DRE and multiple PVNHs. Following surgery, aesthetic industries had been undamaged, highlighting the many benefits of otherwise tractographic reconstruction. At year postoperatively, the individual stayed seizure totally free, suggesting the possibility efficacy of focusing on a single heterotopia within complex systems in well-selected situations. The video clip are found here https//stream.cadmore.media/r10.3171/2024.4.FOCVID2417. We reported two instances of postoperative CA after gynecological surgery and reviewed the clinical popular features of 140 patients from 16 relevant documents. Customers’ clinicopathological faculties, medical approach, and administration had been summarized. The beginning and resolution times during the postoperative CA in different groups were examined individually. The 2 clients inside our report had data recovery after conventional treatments. In accordance with the literary works review, the median period of start of postoperative CA ended up being 5 times (range, 0-75 days) after surgery. The median quality time was 9 days (range, 2-90 days). Among clients, 87.14% of them had lymphadenectomy during gynecological surgeries, while 92.86% of the patients had resolution after traditional remedies. Lymphadenectomy during surgery could be highly relevant to the postoperative CA. Conventional management could be the initial choice for postoperative CA therapy.