On the basis of the full residential and job histories, lifetime time-varying exposure assessment will be performed. thenthereby For example, by means of geospatial environmental exposure modelling (eg, air pollution or radiofrequency electromagnetic fields from mobile phone base stations) linked to the geocoded residential histories, and by means of job exposure matrices (eg, on various chemical and physical exposures) linked

to coded job histories according to the International Classification of Occupations (ISCO).9 The screening questions across the job history on electromagnetic field exposures included whether participants ever worked with or near certain exposure sources, for example, electrical welding,

antitheft devices in shops. The shift work screening questions addressed whether participants ever worked in shifts other than daytime shifts (eg, night shift, evening shift, etc), and, if so, when they started and stopped, and for night shift, the average number of nights per months in that period. The second part of the baseline questionnaire addressed self-reported health, including general health, headache

(Headache impact test,10 ID Migraine11), sleep (Medical Outcomes Study (MOS)-Sleep12), memory problems, hearing problems, tinnitus, early Parkinson symptoms,13 somatisation symptoms based on the Four-Dimensional Symptom Questionnaire,14 respiratory symptoms based on the European Community Respiratory Health Survey (ECRHS15 16); doctor-diagnosed diseases and age at diagnosis, including diabetes, cardiovascular, neurological, AV-951 pulmonary, gastrointestinal, musculoskeletal diseases; family history of major diseases; recent major negative life events based on the Social Readjustment Rating Scale;17 perceived environmental exposures, risk perception and attribution of symptoms to environmental factors. Those who provided a valid email address on registration but did not complete the first part of the questionnaire received a reminder email after approximately 2 weeks with the link to the questionnaire and a request to complete it.