It is unclear whether this is a primary consequence of the disease or whether it is secondary to low activity, decrease in outdoor activity, selleck low vitamin D 25(OH)D (VITD) levels or other factors (medications). There is emerging evidence that low VITD levels and reduced physical activity (PA) may negatively affect BMD in MS. Elevated pro-inflammatory cytokines [i.e. IL-6, soluble tumor necrosis factor II (sTNFRII), and interleukin-10 (IL-10)] and increased cortisol levels also appear inversely related to BMD in persons without MS.
METHODS: In this study, we examined the associations for VITD, PA, endogenous cortisol, and cytokines with BMD in MS patients. Measurements were made in 23 Doramapimod ic50 community dwelling adults volunteers with MS and 21 age-matched controls. The lumbar spine (L2-L4) and femoral neck BMD Selleckchem PLX4720 were measured with dual X-ray absorptiometry (DXA, lunar prodigy) and physical activity was measured with accelerometers (average of 7 day recording). Vitamin D, cortisol, and cytokines (IL-6, sTNFRII and IL-10) were measured by RIA or EIA. Analyses were by unpaired t-tests and Pearson
correlations. The results showed that MS subjects compared with controls had differences in PA (p < 0.05), IL-6 (p = 0.01), sTNFRII (p = 0.001) and mean femoral neck BMD (p = 0.04). No differences were noted in lumbar spine, VITD or cortisol. In our sample (N = 23 MS), VITD levels were normal and not different from CN with most of the MS group reporting VITD supplementation. VITD levels did not correlate with BMD. Within the MS group alone, PA was correlated to femoral BMD (r = 0.48, p = 0.02) but not lumbar spine (r = −0.14, p = 0.56). However, BMD was NOT significantly correlated with cortisol, sTNFRII, or IL-10. IL-6 was inversely correlated to PA within the MS group (r = −0.40, p = 0.05). CONCLUSION: In patients with MS who are replete with VITD, Physical Activity is a major contributor to BMD of the femoral
neck. IL-6 levels may be a factor in the total physical activity of MS patients. Furthermore, low BMD was measured in at least one site in 11 of 23 patients with MS (48 %) but in only three control subjects (14 %) indicating a need to monitor BMD in this rather young (mean age 41 + 9 years) patient population. SPTLC1 The results also suggest that importance of promoting physical activity to improve BMD and decrease fracture risk in persons with MS. P11 THE RELATIVE IMPORTANCE OF 13 DIFFERENT TYPES OF PRESCRIPTION-MEDICATION INFORMATION TO 1,280 U.S. WOMEN WITH OSTEOPOROSIS Colleen A. McHorney, PhD, Merck & Co., Inc., North Wales, PA BACKGROUND: Chronically-ill patients report significant unmet information needs about their medications (Rx). Only a handful of studies have been conducted among women with osteoporosis. OBJECTIVE: To assess the importance 1,280 U.S. women with osteoporosis attach to 13 types of Rx information. METHODS: A cross-sectional survey of U.S.