In the amygdala, subsequent ontological analyses using the GOMiner algorithm demonstrated significant enrichment in categories related to cytoskeletal reorganization and cation transport, as well as in gene families related to synaptic transmission and neurogenesis. In the hippocampus, significant enrichment in gene expression within categories related to cytoskeletal reorganization and cation transport was similarly observed. Furthermore, unique to the hippocampus, enrichment in transcription factor activity and GTPase-mediated signal transduction was identified. Overall, these data identify specific and unique neurochemical pathways chronically altered following VX-809 inhibitor kindling in
the two sites, and provide a platform for defining the molecular basis for the differential behaviors observed in the interictal period.”
“Gamma-melanocyte stimulating hormone (gamma-MSH) is a peptide derived from the ACTH precursor, proopiomelanocortin (POMC), and belongs to a family of peptides called the melanocortins that also comprises alpha- and beta-MSH. Although conserved in tetrapods, the biological role of gamma-MSH remains largely undefined. It has been demonstrated previously that gamma-MSH is involved in the regulating the activity of hormone sensitive lipase (HSL) activity in the adrenal and more recently, in the adipocyte. It has been shown also to have effects on the cardiovascular and renal systems.\n\nThis short review will provide a
brief overview of the role of gamma-MSH in the adrenal and the more recent report that it can also regulate HSL function in the adipocyte. We also present some preliminary data purporting a direct role for Lys-gamma(3)-MSH find more in the regulation of HSL phosphorylation in the heart. Taken together these data suggest that gamma-MSH peptides might play a more widespread role in lipid and cholesterol utilization. (C) 2008 Elsevier Ireland Ltd. All rights reserved.”
“Background: Although there are increasing numbers of long-term survivors
on dialysis, there is remarkably little information about their medical and social wellbeing. Methods: A group of 46 current survivors of long-term dialysis at a single centre were identified and asked to complete a structured interview; selected routine blood tests were also reviewed. The group’s background and renal replacement history PP2 cost are described, along with frequencies of various complications. Results: Younger age and non-diabetic renal disease are associated with longer survival. Substantial morbidity accumulated over the time on dialysis, particularly vascular disease ( 57%) which was strongly linked to smoking history, as well as musculoskeletal complications ( 78%) and nutritional decline ( 80%). Encapsulating peritoneal sclerosis developed in 4 patients, after between 9 and 13 years of peritoneal dialysis. Conclusions: Despite accumulating morbidity, a surprisingly stable and socially well- adjusted group is revealed, with low rates of hospital admission in the majority.