Hadingham KL, Wingrove P, Le Bourdelles B, Palmer KJ, Ragan CI, Whiting PJ. Cloning of cDNA sequences encoding human alpha 2 and alpha 3 learn more gamma-aminobutyric acid A receptor subunits and characterization of the benzodiazepine pharmacology of recombinant alpha 1-, alpha 2-, alpha 3-, and alpha 5-containing human gamma-aminobutyric acid A receptors. Mol

Pharmacol. 1993;43:970–5.PubMed 25. Watanabe Y, Shibuya T, Khatami S, Salafsky B. Comparison of typical and atypical benzodiazepines on the central and peripheral benzodiazepine receptors. Jpn J Pharmacol. 1986;42:189–97.PubMedCrossRef 26. Greenblatt DJ, Harmatz JS, von Moltke LL, Wright CE, Durol AL, Harrel-Joseph LM, Shader RI. Comparative kinetics and response to the benzodiazepine agonists triazolam and zolpidem: evaluation of sex-dependent differences. J Pharmacol Exp Ther. 2000;293:435–43.PubMed 27. Greenblatt DJ, Selleckchem 4EGI-1 Harmatz JS, von Moltke LL, Ehrenberg BL, Harrel L, Corbett K, Counihan M, Graf JA, Darwish M, Mertzanis P, Martin PT, Cevallos WH, Shader RI. Comparative kinetics and dynamics of zaleplon, zolpidem, and placebo. Clin Pharmacol Ther. 1998;64:553–61.PubMedCrossRef 28. Gustavson LE, Carrigan PJ. The clinical pharmacokinetics of single doses

of estazolam. Am J Med. 1990;88:2S–5S.PubMedCrossRef 29. Saari TI, Laine K, Leino K, Valtonen M, Neuvonen PJ, Olkkola KT. Effect of voriconazole on the pharmacokinetics and pharmacodynamics of zolpidem buy SRT2104 in healthy subjects. Br J Clin Pharmacol. 2007;63:116–20.PubMedCrossRef 30. Olubodun JO, Ochs HR, von Moltke LL, Roubenoff R, Hesse LM, Harmatz JS, Shader RI, Greenblatt DJ. Pharmacokinetic properties of zolpidem in elderly and young

adults: possible modulation by testosterone in men. Br J Clin Pharmacol. 2003;56:297–304.PubMedCrossRef 31. Tornio A, Neuvonen PJ, Backman JT. The CYP2C8 inhibitor gemfibrozil does not increase the plasma concentrations of zopiclone. Eur J Clin Pharmacol. 2006;62:645–51.PubMedCrossRef Methane monooxygenase 32. Nakajima T, Takazawa S, Hayashida S, Nakagome K, Sasaki T, Kanno O. Effects of zolpidem and zopiclone on cognitive and attentional function in young healthy volunteers: an event-related potential study. Psychiatry Clin Neurosci. 2000;54:37–40.PubMedCrossRef 33. Villikka K, Kivistö KT, Lamberg TS, Kantola T, Neuvonen PJ. Concentrations and effects of zopiclone are greatly reduced by rifampicin. Br J Clin Pharmacol. 1997;43:471–4.PubMedCrossRef 34. Tokairin T, Fukasawa T, Yasui-Furukori N, Aoshima T, Suzuki A, Inoue Y, Tateishi T, Otani K. Inhibition of the metabolism of brotizolam by erythromycin in humans: in vivo evidence for the involvement of CYP3A4 in brotizolam metabolism. Br J Clin Pharmacol. 2005;60:172–5.PubMedCrossRef 35. Osanai T, Ohkubo T, Yasui N, Kondo T, Kaneko S. Effect of itraconazole on the pharmacokinetics and pharmacodynamics of a single oral dose of brotizolam. Br J Clin Pharmacol. 2004;58:476–81.PubMedCrossRef 36.