Among a sample of 486 SB-715992 supplier persons (mean age: 83.5 years) living in a residential care setting, PA and NA were found to be modestly negatively correlated (r=-0.26).2

This degree of relationship exemplifies their relative independence while still being negatively correlated. Furthermore, concurrent correlations showed that NA was correlated with Geriatric Depression Scale (GDS, r=0.61),3 Profile of Moods States (POMS),4 POMS Anger subscale (r=0.56), POMS Vigor subscale (r=-0.30), total sum of the Cumulative Illness Rating Scale (CIRS, r=-0.22;),5 and activities of daily living (r=-0.29).6 On the other hand, PA was correlated with GDS (r=-0.68), Inhibitors,research,lifescience,medical POMS Anger (r=-0.30), POMS Vigor (r=0.74), Inhibitors,research,lifescience,medical CIRS (r=0.23), and activities of daily living (r=0.27), but in the opposite direction. In the study noted above, older persons were asked specifically to rate the states defining NA and PA. However, in a clinical interview, the patient may not be asked to report affective states Inhibitors,research,lifescience,medical so succinctly Unless asked directly, older persons may be reluctant to report negative affect. Lyness and colleagues7 found that persons older than 60 years who had been diagnosed as major dépressives underreported their depressive symptoms. Similarly, Gallo et al8 warned of a subgroup of older persons who exhibit nondysphoric depression. They found

that persons who reported other depressive symptoms, but denied sadness or dysphoria, were at a higher risk for death (relative risk, RR=1.70), impairment in activities of daily living (RR=3.76), impairment in instrumental activities of daily living (RR=5.07), psychological distress Inhibitors,research,lifescience,medical (RR=3.68), and Inhibitors,research,lifescience,medical cognitive impairment (RR=3.00) 13 years later. Measuring affective states over time is also important in order to take individual differences in stability and lability of emotion into account, and repeated measurement could be beneficial in determining treatment outcomes. Lawton et al9 collected daily

affect data for 30 days among a sample of 78 residential care persons (mean age: 82.8 years). Nineteen persons had been diagnosed with major depression, 21 had minor depression, and 37 were nondepressed. Intersubject variability was determined by summing the residents’ individual scores over the 30-day period Oxalosuccinic acid and computing z scores. As expected, mean levels of PA were highest in nondepressed persons and lowest in major dépressives. NA was lowest in nondepressed persons and highest in persons with major depression. Intrasubject variability was also examined, and daily variability in PA was low, and at a very low level of positive feeling, among persons diagnosed with major depression, whereas daily variability in NA was least among nondepressed persons.