A 1 2 The Drug:H+

A.1.2 The Drug:H+ Antiporter-1 (12 Spanner) (DHA1) Family drug, polyamine, neurotransmitter, sugar, nucleobase/side, siderophore, lipid (antiport); vitamin (symport) 12 9 2.A.1.3 The Drug:H+ Antiporter-2 (14 Spanner) (DHA2) Family drug, boron, bile acid, parquot, fatty acid, siderophore, amino acid (antiport); pyrimidine (symport) 49 6 2.A.1.4 The Organophosphate:Pi Antiporter (OPA) Family carbohydrate phosphate (antiport)

  1 2.A.1.6 The Metabolite:H+ Symporter (MHS) Family organic acid/base, sugar acid (symport) 6 1 2.A.1.8 The Nitrate/Nitrite Porter (NNP) family nitrate/nitrite (symport/antiport) 2 1 2.A.1.11 The Oxalate:Formate Antiporter (OFA) Family oxalate/formate (antiport) 3   2.A.1.14 The Anion:Cation Symporter (ACS) Family organic and inorganic anion, see more peptide, vitamin, amino acid, nucleotide (uniport; symport) 3   2.A.1.15 The Aromatic Acid:H+ Symporter (AAHS) Family aromatic acid, vitamin (symport) 3 1 2.A.1.17 The Cyanate Porter (CP) Family cyanate, glucose (symport) 3   2.A.1.21 The Drug:H+ Antiporter-3 (12 Spanner) (DHA3) Family drug, siderophore (antiport) 6 7 2.A.1.24 The Unknown Major Facilitator-1 (UMF1) Family unknown 1 1 2.A.1.25 Gamma-secretase inhibitor The Peptide-Acetyl-Coenzyme A Transporter (PAT) Family

peptide, glycopeptide, acyl-CoA (symport)   3 2.A.1.30 The Putative Abietane Diterpenoid Transporter (ADT) Family diterpenoid (symport) 4   2.A.1.34 The Sensor Kinase-MFS Fusion (SK-MFS) Family unknown 1   2.A.1.35 The Fosmidomycin Resistance (Fsr) Family drug (antiport) 1   2.A.1.36 The Acriflavin-sensitivity (YnfM) Family drug (symport) 2 1 2.A.1.40 The Purine Transporter, AzgA (AzgA) Family purine (symport) 2   2.A.1.49 The Endosomal Spinster (Spinster) Family unknown   1 2.A.1.54 The Unknown (Archaeal/Bacterial) Major Facilitator-9 (UMF9) Family unknown 1   2.A.1.60 The Rhizopine-related MocC (MocC) Family rhizopine 7 1 2.A.1.67 The Unidentified Major Facilitator-16 (UMF16) Family unknown 5   2.A.17 The Proton-dependent Oligopeptide Transporter (POT) Family peptide, histidine, Carnitine palmitoyltransferase II nitrate (Epoxomicin manufacturer symport; occasionally

antiport) 1 2 Representation of transporters belonging to known families within the Major Facilitator Superfamily (MFS) listed according to TC number with their substrate ranges and modes of active transport indicated. Drug exporters are prevalent in both organisms. The DHA1 Family (2.A.1.2) has 12 members in Sco and nine in Mxa, the DHA2 Family (2.A.1.3) has 49 members in Sco and six in Mxa, and the DHA3 Family (2.A.1.21) has six and seven members in these two organisms, respectively. It is clear that Sco, but not Mxa, has greatly increased its numbers of DHA2 family members, although neither did for DHA1 or DHA3 family members. The order of representation is therefore DHA2 >DHA1>DHA3 in Sco, with huge representation of DHA2 members, but DHA1 > DHA3 > DHA2 in Mxa, with much lower representation overall.

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