4 Insomnia is a diagnostic criterion or a clinical feature of several psychiatric disorders.5 A large analysis of studies of sleep pattern characteristics of psychiatric disorders documented the ubiquity of insomnia among patients with mood disorders, alcoholism, anxiety disorders, borderline personality disorder, schizophrenia, and dementia.6 Among the effects, sleep continuity disturbances were the most prevalent. Results

obtained in epidemiological, cross-sectional, and longitudinal studies suggest a high rate of comorbidity between sleep disturbance and psychopathology, and most specifically with insomnia, anxiety, and depression. Although there is a positive relationship between severity Inhibitors,research,lifescience,medical of sleep disturbances and concurrent psychopathology, unequivocal evidence of a cause-and-effect relationship is still lacking.7 However, longitudinal data suggest that anxiety and stressful life events often precede acute sleep difficulties, whereas persistent insomnia may be a risk factor for subsequent development of depression. Inhibitors,research,lifescience,medical Complaints of 2 weeks or more of

insomnia nearly every day might be a useful marker of subsequent onset of major depression.8 Although more than 40% of subjects with sleep complaints had diagnosable psychiatric disorders,4,9 it is unclear whether abnormal polysomnographic findings could be prevalent in subjects with Inhibitors,research,lifescience,medical sleep complaints and underlying psychiatric disorders.10 Phasic events: arousals The criteria given for SNS-032 arousal in sleep refer to a rapid shift towards more rapid frequencies preceded by at least 10 s of continuous sleep.11 In the American Sleep Disorders Association (ASDA) definition, arousals are

basically considered as markers of sleep disorders.11 However, arousals Inhibitors,research,lifescience,medical are usual EEG features in normal sleep,12 even though they are also clearly influenced by the environment of the sleeper.13 The term “arousal” is often related to the concept of awakening, but in multiple cases, arousal is limited in length and amplitude, and it does not lead to the state of wakefulness (desynchronized, low amplitude, and fast EEG activities Inhibitors,research,lifescience,medical seen on all recording sites). Arousals, for not instance, are important in the determination of the possible impact of sleep disturbance on daytime sleepiness. However, arousals vary in intensity and frequency during sleep. Bonnet14 investigated three levels of arousal responses: full awakening requiring a verbal response; body movement; and transient EEG arousal. Daytime effects of recurrent pathological arousals could be related not only to the sleep stage transition from deep sleep to shallower sleep stages, but also to the difficulty in returning rapidly to these initial states.15 Minor arousals are almost always associated with autonomic changes that reflect the underlying sympathetic activation, such as heart rate, blood pressure, peripheral vasoconstriction, or skin responses.