2a e 2b). O exame histológico revelou tratar-se de uma neoplasia neuroendócrina bem diferenciada (figs. 3a e

3b) e com baixo índice proliferativo (Ki67 < 5% - fig. 3c). Os tumores neuroendócrinos são raros LDK378 e têm um crescimento indolente e silencioso sendo responsáveis por um terço das neoplasias do intestino delgado. A multifocalidade foi reportada em até 30% dos casos. Geralmente tornam-se sintomáticos quando já metastizados enquanto o tumor primário é ainda pequeno. A identificação do tumor primário foi, até recentemente, muito difícil, mas a introdução na prática clínica de novas técnicas para avaliar o intestino delgado melhoraram o seu diagnóstico2 and 3. A deteção do tumor primário parece importante mesmo em doença metastática, já que, a ressecção cirúrgica está associada a um melhor prognóstico4. Da revisão da literatura efetuada este é o segundo caso de carcinóide multifocal do intestino delgado diagnosticado pré-operatoriamente por EDB5. Os autores declaram não haver conflito de BTK high throughput screening interesses. “
“Whipple‘s disease is a rare systemic disorder with unspecific signs and symptoms, that remains a diagnostic challenge.1

A 61-year-old female was referred to the gastroenterology department due to abdominal pain, diarrhea and arthralgias. The investigation revealed anemia, hypoalbuminemia and inflammatory markers’ elevation, with normal immunological investigation. Fecal smears were positive for Giardia lamblia, but after effective treatment she remained symptomatic. Colonoscopy was normal and the upper endoscopy revealed edematous mucosa on the second duodenal portion. Histopathology of the duodenal biopsy revealed macrophages Galeterone infiltration, inconclusive for periodic acid-schiff and negative for Ziehl–Nielsen stains. However, polymerase chain reaction (PCR) for Tropheryma whipplei was positive.

A capsule endoscopy revealed areas of whitish reticular pattern and dilated villi with lymphangiectasias in the jejunum and ileum ( Figure 1 and Figure 2), changes suggestive of Whipple’s disease. Antibiotherapy with ceftriaxone followed by trimethoprim-sulfamethoxazole was done. After eight months of treatment, the patient was asymptomatic; anterograde and retrograde single-balloon enteroscopy were performed revealing resolution of the lesions, and the biopsies had negative histological findings and PCR for Tropheryma whipplei. There are few reports regarding the appearance of the small bowel in Whipple’s disease as viewed by capsule endoscopy, but a pattern of mucosal involvement with patchy white-yellowish punctate miliaria is considered suggestive.2 and 3 However, in the present case these changes occurred throughout the jejunum and ileum and were absent in the duodenum.