002 for all sleep parameters). After adjusting for multiple potential confounders, self-reported Alisertib in vivo poor sleep

quality (Pittsburgh Sleep Quality Index > 5, multivariable odds ratio (MOR)=1.28, 95% confidence interval (CI)=1.09-1.50), sleep efficiency less than 70% (MOR=1.37, 95% CI=1.12-1.67), sleep latency of 60 minutes or longer (MOR=1.42, 95% CI=1.10-1.82), and sleep-disordered breathing (respiratory disturbance index >= 15, MOR=1.38, 95% CI=1.15-1.65) were each independently associated with higher odds of greater frailty status.\n\nCONCLUSION\n\nSleep disturbances, including poor self-reported sleep quality, lower sleep efficiency, prolonged sleep latency, and sleep-disordered breathing, are independently associated with greater evidence of frailty.”
“Background: A 13-valent pneumococcal conjugate vaccine (PCV13) containing 6 additional serotypes not included in the 7-valent PCV has been developed to broaden protection against Streptococcus pneumoniae, which is responsible for over 500,000 deaths annually worldwide in children <5 years of age.

This study in Japanese infants evaluated the immunogenicity and safety of PCV13 given subcutaneously, the standard route for infant vaccination EVP4593 mw in Japan.\n\nMethods: This phase 3, single-arm, open-label study was conducted at 25 sites. Subjects received PCV13 as a 3-dose infant series and a toddler dose. Parents/legal guardians recorded local reactions and systemic events after each vaccination. The proportion of subjects with serotype-specific antipneumococcal polysaccharide immunoglobulin (Ig)G antibody concentrations >= 0.35 mu g/mL was calculated before and 1 month after the infant series and toddler dose.\n\nResults: A total of 193 subjects enrolled. The proportion of subjects achieving pneumococcal IgG antibody concentrations >= 0.35 mu g/mL was >= 97.2% for all 13 pneumococcal serotypes 1 month after the infant series and 98.9-100% after the toddler dose. IgG geometric mean concentrations were

2.57-14.69 mu g/mL after the infant series and 2.06-16.33 mu g/mL after the toddler dose. IgG geometric mean concentrations increased from pre- to posttoddler dose by >= 2.8-fold, demonstrating a booster effect. Local HDAC inhibitor reactions and fever were generally mild or moderate in severity.\n\nConclusions: PCV13 was immunogenic for all serotypes and had a favorable safety profile when administered subcutaneously to Japanese infants. PCV13 should offer broader serotype protection than 7-valent PCV in preventing pneumococcal disease in Japanese children.”
“Addition of 0.5% onion was effective in reducing lipid oxidation in irradiated cooked ground beef after 7 day storage. Addition of garlic or onion greatly increased the amounts of sulfur volatiles from cooked ground beef.