Multiple studies have found that older individuals have discernible differences in these measurements. Thelen et al. compared muscle activities in young and elderly subjects and found that the latter

showed delays in activating the hip flexors and knee extensors during the period in which the stepping leg is swung into position [84, 85]. Wojcik et al. found that elderly adults generate lower hip flexion and extension torques than young adults during single-step recoveries after being placed at a forward www.selleckchem.com/products/cobimetinib-gdc-0973-rg7420.html lean angle [86, 87]. Thus, there is evidence that reduced strength of the hip and other lower-leg muscles, in addition to impaired neuromuscular activation, may be implicated in poor recovery from falls. In addition to falls, muscle weakness and reduced muscle mass have been associated with incident disability. The Health, Aging, and Body Composition Apoptosis antagonist Study investigators carried out studies of body composition, muscle strength, and other risk factors on incident mobility limitation, defined as inability to walk a quarter mile or climb a flight

of ten stairs. Visser et al. observed that low-thigh muscle CSA measured at baseline resulted in a 45% and 34% increased risk of mobility limitations 5 years later in men and women, respectively [88]. For low-knee extensor power and torque, the risk of incident mobility limitation was even higher, at 66% and 69% for men and women, respectively [88]. The same study found that men and women in the lowest quartile of thigh muscle cross-sectional area and leg muscle mass had a 30–40% increase of risk for the inability to carry out the activities of daily living. For major disability, which includes inability to carry out activities of daily living, inability to walk a quarter mile, or climb ten steps, low-thigh CSA increased risk by 40% whereas low-knee extensor strength resulted in over a doubling of the risk. These subjects were also followed up for incident hospitalizations,

and low-thigh CSA and muscle strength showed a similar predictive power for this outcome. Thigh muscle cross-sectional area and knee extension find more torque have also been shown to correlate to incident hip fracture in the Health ABC study [89]. Lang et al. observed that knee extension torque and low cross-sectional RVX-208 area individually resulted in increased risk of incident hip fracture by 50–60%, independent of bone mineral density (BMD). The increased risk of mobility loss and injury resulting from loss of muscle mass and power are part of a vicious cycle which is amplified with age. In addition to reductions in performance, the intermediate consequences of muscle loss include reductions in metabolic rate and aerobic capacity. The loss of power and endurance increase the difficulties associated with procuring adequate nutrition and increase the effort required to undertake exercise.