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“Dear Editor, We read with interest the article by Kim et al., which showed the association between higher serum ferritin level and lower bone mineral density in women ≥45 years of age [1]. We have several concerns on the article. First, the authors analyzed data from the Korean National Health and Nutrition Survey (KNHANES), which was a nationally representative cross-sectional survey of the civilian, non-instutionalized Korean PRKACG population. KNHANES used a sampling design that involved a complex stratified, multistage, probability cluster survey method, and special statistical methods such as sample weighting, are thus required to properly analyze the survey data [2]. However, the authors analyzed the data without consideration of sample weighting. Analyses of these data using traditional statistical software (such as SPSS) that use ordinary and generalized least squares estimation techniques tend to LY2606368 purchase result in an underestimated standard error, inappropriate confidence intervals, and misleading tests of significance [3].