There is a need for psychiatrists and other medical specialists to be aware of this life-threatening side effect of clozapine. Footnotes Funding: This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors. Conflict of interest statement: The authors declare no conflicts of interest
in preparing this article. Contributor Information Kazeem Olaide Adebayo, Department Inhibitors,research,lifescience,medical of Psychiatry, Ladoke Akintola University Teaching Hospital, Osogbo, Nigeria. Nurudeen Ibrahim, Department of Psychiatry, Ladoke Akintola University Teaching Hospital, Osogbo, Nigeria. Temilola Mosanya, Department of Psychiatry, Ladoke Akintola University Teaching Hospital, Osogbo, Nigeria. Benjamin Eegunranti, Department of Psychiatry, Ladoke Akintola University Teaching Hospital, Osogbo, Nigeria. Babatunde Suleiman, Department of Psychiatry, Ladoke Akintola University Teaching Hospital, Ogbomoso, Nigeria. Akeem Ayankunle, Department of Pharmacology and Therapeutics, LAUTECH University, Inhibitors,research,lifescience,medical Ogbomoso, Nigeria.
Schizophrenia is a chronic, disabling disease that requires long-term treatment. Remission is increasingly recognized by clinicians and researchers as a particularly important outcome measure when treating schizophrenia and related disorders [{Selleck Anti-infection Compound Library|Selleck Antiinfection Compound Library|Selleck Anti-infection Compound Library|Selleck Antiinfection Compound Library|Selleckchem Anti-infection Compound Library|Selleckchem Antiinfection Compound Library|Selleckchem Anti-infection Compound Library|Selleckchem Antiinfection Compound Library|Anti-infection Compound Library|Antiinfection Compound Library|Anti-infection Compound Library|Antiinfection Compound Library|Anti-infection Compound Library|Antiinfection Compound Library|Anti-infection Compound Library|Antiinfection Compound Library|Anti-infection Compound Library|Antiinfection Compound Library|Anti-infection Compound Library|Antiinfection Compound Library|Anti-infection Compound Library|Antiinfection Compound Library|Anti-infection Compound Library|Antiinfection Compound Library|Anti-infection Compound Library|Antiinfection Compound Library|buy Anti-infection Compound Library|Anti-infection Compound Library ic50|Anti-infection Compound Library price|Anti-infection Compound Library cost|Anti-infection Compound Library solubility dmso|Anti-infection Compound Library purchase|Anti-infection Compound Library manufacturer|Anti-infection Compound Library research buy|Anti-infection Compound Library order|Anti-infection Compound Library mouse|Anti-infection Compound Library chemical structure|Anti-infection Compound Library mw|Anti-infection Compound Library molecular weight|Anti-infection Compound Library datasheet|Anti-infection Compound Library supplier|Anti-infection Compound Library in vitro|Anti-infection Compound Library cell line|Anti-infection Compound Library concentration|Anti-infection Compound Library nmr|Anti-infection Compound Library in vivo|Anti-infection Compound Library clinical trial|Anti-infection Compound Library cell assay|Anti-infection Compound Library screening|Anti-infection Compound Library high throughput|buy Antiinfection Compound Library|Antiinfection Compound Library ic50|Antiinfection Compound Library price|Antiinfection Compound Library cost|Antiinfection Compound Library solubility dmso|Antiinfection Compound Library purchase|Antiinfection Compound Library manufacturer|Antiinfection Compound Library research buy|Antiinfection Compound Library order|Antiinfection Compound Library chemical structure|Antiinfection Compound Library datasheet|Antiinfection Compound Library supplier|Antiinfection Compound Library in vitro|Antiinfection Compound Library cell line|Antiinfection Compound Library concentration|Antiinfection Compound Library clinical trial|Antiinfection Compound Library cell assay|Antiinfection Compound Library screening|Antiinfection Compound Library high throughput|Anti-infection Compound high throughput screening| Davidson et al. 2008]. The Schizophrenia Working Group
has defined remission Inhibitors,research,lifescience,medical as achieving and maintaining symptoms of schizophrenia that are mild or less over a 6-month period [Andreasen et al. 2005]. This definition has been utilized in numerous studies investigating schizophrenia outcome [Ciudad et al. 2009; Díaz et al. 2012; Dunayevich et al. 2006; Haynes et al. 2012; Lambert Inhibitors,research,lifescience,medical et al. 2010; San et al. 2007; Wunderink et al. 2007]. Unfortunately, effective long-term symptom improvement Inhibitors,research,lifescience,medical is often complicated by symptomatic relapse [Schooler, 2006]. Treatment nonadherence is a major risk factor for relapse [Leucht and Heres, 2006], with medication nonadherence affecting nearly half of all outpatients with schizophrenia
treated for 1 year [Rosa et al. 2005]. A variety of factors contribute to poor treatment adherence, including poor treatment tolerability [Yamada et al. 2006], poor insight, health beliefs, the patient or family being opposed to medications, problems with treatment access, embarrassment/stigma over illness, no perceived daily benefit, medication interference with life goals, poor therapeutic alliance, Mephenoxalone complicated treatment regimen, cognitive dysfunction, and lack of social support [Dolder et al. 2002; Kane, 2007; Linden and Godemann, 2007; Löffler et al. 2003]. Medication adherence may be improved by treating patients with long-acting antipsychotic formulations [Kane, 2006; Leucht and Heres, 2006; Schooler, 2003] and selecting better-tolerated atypical antipsychotics compared with conventional neuroleptics [Dolder et al. 2002].