Cancer Res 2012, 72:1290–1300 PubMedCrossRef 32 Baritaki S, Chap

Cancer Res 2012, 72:1290–1300.PubMedCrossRef 32. Baritaki S, Chapman A, Yeung K, Spandidos DA, Palladino M, Bonavida B: Inhibition of epithelial to mesenchymal transition in metastatic prostate cancer cells by the novel proteasome inhibitor, NPI-0052: pivotal roles of Snail repression and RKIP induction. Oncogene 2009, 28:3573–3585.PubMedCrossRef 33. Mundy GR: Metastasis to bone: causes, consequences and therapeutic opportunities. Nat Rev Cancer 2002, 2:584–593.PubMedCrossRef 34.

Dougall WC, Chaisson M: The RANK/RANKL/OPG triad in cancer-induced bone diseases. Cancer Metastasis Rev 2006, 25:541–549.PubMedCrossRef 35. Watson MA, Ylagan LR, Trinkaus KM, Gillanders WE, Naughton MJ, Weilbaecher KN, FG-4592 datasheet Fleming TP, Aft RL: Isolation and molecular profiling of bone marrow micrometastases identifies TWIST1 as a marker of early tumor relapse in breast Histone Methyltransferase inhibitor & DOT1 inhibitor cancer patients. Clin Cancer Res 2007, 13:5001–5009.PubMedCrossRef 36. Sihto H, Lundin J, Lundin M, Lehtimäki T, Ristimäki A, Holli K, Sailas L, Kataja V, Turpeenniemi-Hujanen T, Isola J, Heikkilä P, Joensuu H: Breast cancer biological subtypes and protein expression predict for the preferential

distant metastasis sites: a nationwide cohort study. Breast Cancer Res 2011, 13:R87.PubMedCrossRef 37. Canon JR, Roudier M, Bryant R, Morony S, Stolina M, Kostenuik PJ, Dougall WC: Inhibition of RANKL blocks skeletal tumor progression and improves survival in a mouse model of breast cancer bone CRT0066101 concentration Molecular motor metastasis. Clin Exp Metastasis 2008, 25:119–129.PubMedCrossRef Competing

interests The authors declare that they have no competing interests. Authors’ contributions MT carried out analysis of EMT, western blotting analysis, real time PCR, migration and invasion assays, statistical analysis, and drafted the manuscript. MK and SF carried out analysis of EMT, western blotting analysis. TI, TS, MI, KS, and HS carried out western blotting analysis. TT, NO, KM, and DF carried out migration and invasion assays. JM, KS, and TS contributed to statistical analyses. SN designed the experiments and revised the manuscript. All authors read and approved the final manuscript.”
“Background Epithelial ovarian cancer (EOC) is the fifth most common cause of cancer mortality in United States and Chinese women [1, 2]. The standard primary treatment paradigm of EOC includes optimal primary cytoreductive surgery (CRS) followed by platinum/paclitaxel based chemotherapy. Although more than half of EOC patients results in a complete clinical response (CCR) through initial therapy, achieving complete cure is infrequent. In fact, about 75% EOC patients develop recurrent disease within 2 years and the mean 5-year survival rate following the radiological defined recurrence is less than 10% [3]. The management of recurrent diseases is one of the key topics and is less clear than that of primary EOC.

Comments are closed.