Then, the patient went to local hospital visiting. Ultrasonic-b abdominal examination showed hepatocirrhosis and splenomegaly.
Esophagogastroduodenoscopy showed esophageal varices and blood routine examination showed pancytopenia. Copy number of HBV-DNA was 1.93×105 cp/ml. The doctor diagnosed the patient as hepatocirrhosis after B hepatitis and gave his comprehensive liver-protecting therapy. However, no amelioration was found in clinical symptoms. So the patient came to our hospital. The patient denied hepatitis history but had a history of blood transfusion because of learn more surgical treatment of left upper arm trauma twenty years ago. After admission, physical examination revealed a temperature of 37°, a pulse rate of 104 beats per minute (bpm), a blood pressure of 146/94 mmHg, and a respiration rate of 18 breaths per minute. There was appearance of anemia, but no liver palms and spider angiomatas. Petechia and ecchymosis didn’t present
on skin all over the body. Superfacial lymph nodes were impalpable. Examination of the heart and lungs revealed no abnormal findings. Abdominal physical examination revealed megalosplenia. The initial laboratory workup was as follows: hemoglobin, 10.8 g/dL; white blood cells, 900/mm3 with a normal differential count; platelets, 42000/mm3; blood glucose, 5.7 mmol/L; APO866 supplier blood urea, 4.8 mmol/L; creatinine, 76 μmol/L; SGOT, 28 IU/L; SGPT, 30 IU/L; LDH, 201 IU/L; total bilirubin, 11.6 μmol/L; direct bilirubin, 5.3 μmol/L; and Na+, 136 mmol/L; K+, 3.9 mmol/L; AFP 2.30 ng/mL, CEA 4.2 9 ng/mL,
CA199 52.28.5 U/mL, higher than normal. Fecal occult blood test was negative. Abdominal computed tomography showed hepatocirrhosis and splenomegaly. He refused bone marrow puncture and demanded partial splenic artery embolization. But laboratory workup was as follows in a month of postoperation: hemoglobin, 100 g/dL; white blood cells, 1100/mm3 with a normal differential count; platelets, 27000/mm3. Bone marrow puncture showed acute lymphoblastic leukemia. Results: Hepatocirrhosis combined acute lymphoblastic leukemia. Conclusion: Hepatocirrhosis patients combining pancytopenia must do bone marrow puncture to exclude hematological diseases. Key Word(s): 1. Hepatocirrhosis; 2. B hepatitis; 3. pancytopenia; 4. acute leukemia; Presenting Author: LIUPING WEI MCE公司 Additional Authors: SHANYU QIN Corresponding Author: SHANYU QIN Affiliations: The First Affiliated Hospital of Guangxi Medical University Objective: To explore the mechanism that bone marrow mesenchymal stem cells (BMSCs) paracrine hepatocyte growth factor (HGF) that effects on apoptosis of hepatic stellate cells (HSCs) and regulation of Rho pathway in vitro. Methods: In this study, cells were divided into the following four groups:○1the blank control group: primary HSCs cultured alone;○2the experimental groups: a.the control group: BMSCs + HSCs; b.HGF inhibitor group: primary HSCs treated with 3 μg/ml of PHA665752; c.